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S-4FB Crosslinker

Manufacturer: Solulink
Shipping: Cold Gel Packs

S-4FB Crosslinker

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S-4FB (SFB) is a heterobifunctional linker that reacts with primary amines on biomolecules and converts them to 4-formylbenzamide (4-FB) linkers. Formylbenzamide-modified biomolecules form stable covalent conjugates when reacted with HyNic-modified biomolecules. 4FB groups incorporated on biomolecules and surfaces are extremely stable and have been known to maintain their reactivity for >18 months.

Solulink’s proprietary linker technology is based on the use of two complementary heterobifunctional linkers:  

  • S-HyNic crosslinker is conjugated to biomolecule 1 through primary amines on proteins, oligos, peptides, or surfaces.
  • S-4FB (succinimidyl-4-formylbenzamide) linker is conjugated to biomolecule 2 through primary amines on proteins, oligos, peptides, carbohydrates, or surfaces.
  • HyNic-modified biomolecule 1 is incubated with 4FB-modified biomolecule 2 to form a conjugate.

The result is two biomolecules conjugated through a UV-traceable and stable bond (bis-arylhydrazone) with measurable absorbance at 354 nm. Thus any two proteins, regardless of molecular weight, can be efficiently conjugated.

Solulink Advantages :

  • Catalyzed Conjugation – Faster kinetics for greater efficiency and yields
  • Quantifiable – Conjugate bond is UV-traceable for simple and direct quantification
  • Stability – 10 times more stable than any other conjugation linker
  • Specificity – Two-linker method avoids homoconjugate formation
  • Efficient – >80% efficient linker-biomolecule conjugations
  • Robust - The conjugate bond is stable to 92˚C and to pH values ranging from pH 2.0–10.0
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SizeCatalogue noPrice 
5 x 1mg size S-1004-105 £185.00/€259.00
1 x 10mg size S-1004-010 £245.00/€343.00

All prices shown are exlusive of VAT.