|Tel :||01904 431402||Bioquote Limited|
The Raylor Centre
York, YO10 3DW
|Fax :||01904 431409|
|Int Tel :||00 44 1904 431402|
|Int Fax :||00 44 1904 431409|
Shipping: Cold Gel Packs
The S-4FB (succinimidyl-4-formylbenzamide) heterobifunctional crosslinker is fundamental to Solulink’s proprietary linker technology. S-SS-4FB is an analog of S-4FB with a cleavable disulfide moiety in the linker enabling intracellular cleavage of the conjugate. S-SS-4FB analog reacts with primary amines on proteins (amino group of lysine), amino-modified oligonucleotides or surfaces, introducing a 4FB (4-formylbenzamide) linker that forms stable covalent conjugates with biomolecules possessing HyNic (6-hydrazinonicotinamide) incorporated linkers. 4FB groups incorporated on biomolecules and surfaces are extremely stable and have been known to maintain their reactivity for >18 months. Intracellularly, disulfide bonds of S-SS-4FB are cleaved by glutathione cleaving a drug payload from its carrier.
Solulink’s proprietary linker technology is based on the use of two complementary heterobifunctional linkers:
The result is two biomolecules conjugated through a UV-traceable and stable bond (bis-arylhydrazone) with measurable absorbance at 354 nm. Thus any two proteins, regardless of molecular weight, can be efficiently conjugated.
|5 x 1mg size||S-1037-105||£195.00/€273.00|
|1 x 10mg size||S-1037-010||£295.00/€413.00|
All prices shown are exlusive of VAT.