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Manufacturer: bioWorld Inc
Shipping: BioWorld Shipping
Myelin Oligodendrocyte Glycoprotein
Background: MOG peptide (35-55) is highly encephalitogenic and can induce strong T and B cell responses. A single injection of this peptide produces a relapsing- remitting neurologic disease with extensive plaque-like demyelination. Because of the clinical, histophathologic, and immunologic similarities with multiple sclerosis (MS), the MOG induced demyelinating encephalomyelitis may serve as a model for investigating MS.
Description : MOG is a single, non-glycosylated polypeptide chain containing 21 amino acids and having a molecular mass of 2582 Dalton.
Physical Appearance: Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation: The protein was lyophilized with no additives.
Solubility: It is recommended to reconstitute the lyophilized MOG in sterile 18MO-cm H2O not less than 100 g/ml, which can then be further diluted to other aqueous solutions.
Stability: Lyophilized MOG although stable at room temperature for 3 weeks, should be stored desiccated below -180C. Upon reconstitution MOG should be stored at 40C between 2-7 days and for future use below -180C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please avoid freeze-thaw cycles.
Purity: Greater than 98.0% as determined by: (a) Analysis by RP-HPLC. (b) Anion-exchange FPLC. (c) Analysis by reducing and non-reducing SDS-PAGE Silver Stained gel.
Amino Acid Composition: H-Met-Glu-Val-Gly-Trp-Tyr-Arg-Ser-Pro-Phe-Ser-Arg-Val-Val-His-Leu-Tyr-Arg-Asn-Gly-Lys-OH.
Dimers and aggregates: Less than 1% as determined by silver-stained SDS-PAGE gel analysis.
Protein content: Protein quantitation was carried out by two independent methods: 1. UV spectroscopy at 280 nm. 2. Analysis by RP-HPLC, using a calibrated solution of MOG as a Reference Standard.
Usage: BioWORLD\\\'s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Storage: should be stored desiccated below -180°C. Upon reconstitution MOG should be stored at 40°C between 2-7 days and for future use below -180°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please avoid freeze-thaw cycles.
Size: 5 mg
Catalog No: 22060604-1 ( 507470 )
All prices shown are exlusive of VAT.