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Myelin Oligodendrocyte Glycoprotein

Manufacturer: bioWorld Inc
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Myelin Oligodendrocyte Glycoprotein

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Myelin Oligodendrocyte Glycoprotein

Background: MOG peptide (35-55) is highly encephalitogenic and can induce strong T and B cell responses. A single injection of this peptide produces a relapsing- remitting neurologic disease with extensive plaque-like demyelination. Because of the clinical, histophathologic, and immunologic similarities with multiple sclerosis (MS), the MOG induced demyelinating encephalomyelitis may serve as a model for investigating MS.

Description : MOG is a single, non-glycosylated polypeptide chain containing 21 amino acids and having a molecular mass of 2582 Dalton.

Physical Appearance: Sterile Filtered White lyophilized (freeze-dried) powder.

Formulation: The protein was lyophilized with no additives.

Solubility: It is recommended to reconstitute the lyophilized MOG in sterile 18MO-cm H2O not less than 100 g/ml, which can then be further diluted to other aqueous solutions.

Stability: Lyophilized MOG although stable at room temperature for 3 weeks, should be stored desiccated below -180C. Upon reconstitution MOG should be stored at 40C between 2-7 days and for future use below -180C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please avoid freeze-thaw cycles.

Purity: Greater than 98.0% as determined by: (a) Analysis by RP-HPLC. (b) Anion-exchange FPLC. (c) Analysis by reducing and non-reducing SDS-PAGE Silver Stained gel.

Amino Acid Composition: H-Met-Glu-Val-Gly-Trp-Tyr-Arg-Ser-Pro-Phe-Ser-Arg-Val-Val-His-Leu-Tyr-Arg-Asn-Gly-Lys-OH.

Dimers and aggregates: Less than 1% as determined by silver-stained SDS-PAGE gel analysis.

Protein content: Protein quantitation was carried out by two independent methods: 1. UV spectroscopy at 280 nm. 2. Analysis by RP-HPLC, using a calibrated solution of MOG as a Reference Standard.

Usage: BioWORLD\\\'s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.


Storage: should be stored desiccated below -180°C. Upon reconstitution MOG should be stored at 40°C between 2-7 days and for future use below -180°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please avoid freeze-thaw cycles.

Size: 5 mg

Catalog No: 22060604-1 ( 507470 )

    Application references:
  • CD24 Controls Expansion and Persistence of Autoreactive T Cells in the Central Nervous System during Experimental Autoimmune Encephalomyelitis;JEMVolume 200, Number 4, 447-458,0022-1007 $8.00,doi:10.1084/jem.20040131  
  • A novel retroviral gene therapy approach to inhibit specific antibody production and suppress experimental autoimmune encephalomyelitis induced by MOG and MBP;Clinical ImmunologyVolume 111, Issue 1, April 2004, Pages 47-52 ,doi:10.1016/j.clim.2003.12.013  
  • Suppression of experimental autoimmune encephalomyelitis by extracellular adherence protein of Staphylococcus aureus;JEMVolume 203, Number 4, 985-994,doi:10.1084/jem.20051681  
  • CC Chemokine Receptor 2 Is Critical for Induction of Experimental Autoimmune Encephalomyelitis;The Journal of Experimental MedicineVolume 192, Number 6, September 18, 2000 899-906,0022-1007/2000/9/899/ $5.00 
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SizeCatalogue noPrice 
5mg size 22060604-1 £269.13/€376.78
Qty:

All prices shown are exlusive of VAT.