|Tel :||01904 431402||Bioquote Limited|
The Raylor Centre
York, YO10 3DW
|Fax :||01904 431409|
|Int Tel :||00 44 1904 431402|
|Int Fax :||00 44 1904 431409|
Manufacturer: ArborAssays Inc
Garcinol is an inhibitor of the histone acetyltransferases (HATs) p300 and PCAF with IC50 of 7 and 5 uM, respectively. It also inhibits the HAT GCN5 in Cryptococcus neoformans, inducing temperature sensitivity and impairing growth. A polyisoprenylated benzophenone isolated from Garcinia indica, garcinol promotes neurogenesis and ex vivo expansion of human hematopoietic stem cells. It induces apoptosis in several types of cancer cells and has anti-inflammatory actions.
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