|Tel :||01904 431402||Bioquote Limited|
The Raylor Centre
York, YO10 3DW
|Fax :||01904 431409|
|Int Tel :||00 44 1904 431402|
|Int Fax :||00 44 1904 431409|
The S-4FB (N-succinimidyl-4-formylbenzamide) heterobifunctional crosslinker is fundamental to Solulink’s proprietary linker technology. The crosslinker is used for direct incorporation of 4FB (4-formylbenzamide) moieties on oligonucleotides during solid phase synthesis. The S-4FB analog reacts with primary amines on proteins (amino group of lysine), amino-modified oligonucleotides or surfaces, introducing a 4FB (4-formylbenzamide) linker that forms stable covalent conjugates with biomolecules possessing HyNic (6-hydrazinonicotinamide) incorporated linkers. 4FB groups incorporated on biomolecules and surfaces are extremely stable and have been known to maintain their reactivity for >18 months.
Solulink’s proprietary linker technology is based on the use of two complementary heterobifunctional linkers:
The result is two biomolecules conjugated through a UV-traceable and stable bond (bis-arylhydrazone) with measurable absorbance at 354 nm. Thus any two proteins, regardless of molecular weight, can be efficiently conjugated.
All prices shown are exlusive of VAT.