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MF63

Manufacturer: ApexBio
Shipping: Standard

Background

MF63 is a selective mPGES-1 inhibitor with an IC50 of 0.9 nM and 1.3 nM for pig mPGES-1 and human mPGES-1 enzyme, respectively. MF63 potently inhibited the human mPGES-1 enzyme with a high degree (>1000-fold) of selectivity over other prostanoid synthases. In rodent species, MF63 strongly inhibited guinea pig mPGES-1 but not the mouse or rat enzyme. When tested in the guinea pig and a knock-in (KI) mouse expressing human mPGES-1, the compound selectively suppressed the synthesis of PGE(2), but not other prostaglandins inhibitable by nonsteroidal anti-inflammatory drugs (NSAIDs), yet retained NSAID-like efficacy at inhibiting lipopolysaccharide-induced pyresis, hyperalgesia, and iodoacetate-induced osteoarthritic pain.

SizeCatalogue noPrice 
5mg size A3600 £85.00/€119.00
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10mg size A3600-10 £115.00/€161.00
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50mg size A3600-50 £245.00/€343.00
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100mg size A3600-100 £395.00/€553.00
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All prices shown are exlusive of VAT.