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Cyn Monkey PXR Reporter Assay System, 1 x 96-well format assays

Manufacturer: Bertin Pharma (formerly SPI Bio)
Shipping: Dry Ice

Cyn Monkey PXR Reporter Assay System, 1 x 96-well format assays

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Product Overview:
This assay product utilizes proprietary human cells engineered to provide constitutive, high-level expression of the Cynomolgus Monkey Pregnane X Receptor (nr1i2), a ligand-dependent transcription factor commonly referred to as PXR. PXR is also known as the Steroid and Xenobiotic sensing nuclear receptor (SXR).
Pregnane X Receptor also known as nuclear receptor subfamily 1, group I, member 2 (NR1I2) and SXR is a nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. PXR activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs, and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones, its response to specific ligands is species-specific. PXR is activated by naturally occurring steroids, such as pregnenolone and progesterone and binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes.

Size : 1 Kit        

Shipping : dry ice 

Stability : Store at -80 degrees; shelf life 180 days maximum after production  

Application(s):

cynomolgus monkey (cPXR)

Specificity:
  • Pregnane X Receptor (PXR; NR1I2)

Custom Code: 3822000002

UNSPSC code: 4111

 

SizeCatalogue noPrice 
1x96 Well Plate size C07001 £635.00/€889.00
Qty:

All prices shown are exlusive of VAT.